2-(4-Nitrophenyl)-4-methoxybenzothiophene → 2-(4-Aminophenyl)-4-methoxybenzothiophene

Participants

Reaction Steps

2-(4-Nitrophenyl)-4-methoxybenzothiophene (1-1, 200 mg, 0.71 mmol) obtained in Example 1 and 10% palladium on charcoal (Pd/C, 5 mg) were added to a round bottom flask containing anhydrous methanol (10 mL) and sealed with a septum. Then, the flask is filled with hydrogen gas, provided with a hydrogen balloon and stirred at room temperature for 12 hours. Then, the resulting product was filtered using celite, and a methanol solvent was removed under reduced pressure to give the target compound 2-(4-aminophenyl)-4-methoxybenzothiophene (1-7, 151 mg, 88%).

Provenance & Evidence