Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 2-[2-(3-Fluoropropoxy)pyrimidine-4-yl]-6-methoxybenzothiophene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3-Fluoro-1-propanol | HCID 68042 | — |
| 반응물 | 2-(2-Chloropyrimidine-4-yl)-6-methoxybenzothiophene | HCID 86646555 | — |
| 생성물 | 2-[2-(3-Fluoropropoxy)pyrimidine-4-yl]-6-methoxybenzothiophene | HCID 46947547 | 65.4% |
반응 단계
2-[2-(3-Fluoropropoxy)pyrimidine-4-yl]-6-methoxybenzothiophene (1-32, 75 mg, 65%) was prepared in the same manner as in Example 31 as a pale yellow solid using 3-fluoro-1-propanol (40 mL, 0.54 mmol), sodium hydride (NaH, 22 mg, 0.54 mmol) and 2-(2-chloropyrimidine-4-yl)-6-methoxybenzothiophene (105a, 100 mg, 0.36 mmol) obtained in Preparation Example 19.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08497260B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-7174684f3c7f4527b7c6cfe771d1f13c |
| 출처 메모 | uspto-grants-2013_07 |