HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium methanolate methanol → 2-(2-Methoxypyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium methanolate methanol | HCID 23694274 | — |
| Reactant | 2-(2-Chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene | HCID 86646557 | — |
| Product | 2-(2-Methoxypyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene | HCID 46947727 | 107.1% |
Reaction Steps
2-(2-Methoxypyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene (1-37, 75 mg, 99%) was prepared in the same manner as in Example 34 as a yellow solid using 2-(2-chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene (105c, 70 mg, 0.22 mmol) obtained in Preparation Example 21 and a 0.5 M sodium methoxide methanol solution (0.66 mL, 0.33 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497260B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-c8fc7ab694bd43689ca6f6e6ee919af6 |
| Source note | uspto-grants-2013_07 |