Morpholine → HCID 178515213, compound

HRID 454836Notes

Reaction equation

HRID 454836 reaction equation
[C:1]1([N:7]2[C:25](=[O:26])[C:10]3=[CH:11][NH:12][C:13]4[CH:14]=[CH:15][C:16]([N:19]5[CH2:24][CH2:23]N[CH2:21][CH2:20]5)=[N:17][C:18]=4[C:9]3=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1CC[O:30]CC1>>[N:19]1([C:16]2[CH:15]=[CH:14][C:13]3[NH:12][CH:11]=[C:10]4[C:25](=[O:26])[N:7]([C:1]5[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=5)[N:8]=[C:9]4[C:18]=3[N:17]=2)[CH2:20][CH2:21][O:30][CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 178515211HCID 178515211, compound

Product 1

HCID 178515213HCID 178515213, compound

Procedure

The title compound was prepared following the procedure described for 6a using morpholine instead of piperazine. 1H-NMR (DMSO-d6) δ (ppm): 3.01 (4H, brm), 3.78 (4H, brm), 7.12 (1H, dt, J=7.56, 7.33 Hz), 7.23 (1H, d, J=9.28 Hz), 7.45 (2H, dd, J=8.54, 7.32 Hz), 7.88 (1H, d, J=9.53 Hz), 8.21 (2H, dd, J=8.55, 1.22 Hz), 8.57 (1H, s). m/z 348.4 (MH+).

Sources & evidence

ORD record
ord-6ab8bdf1068145508f70ff4c45acd5c9
Source dataset
uspto-grants-2013_07
Patent number
US08497262B2

Reaction notes

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