2,4-Difluoroaniline → HCID 45280130, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-bromo-1-(2-methylpyrrolidin-1-yl)phthalazine (325 mg, 1.1 mmol), 2,4-difluorobenzenamine (287 mg, 2.2 mmol), Pd2(dba)3 (10.2 mg, 0.011 mmol), X-Phos (26.5 mg, 0.056 mmol), and potassium carbonate (384 mg, 2.8 mmol) in t-butanol (2.2 mL) was heated at 110° C. in an oil bath for 18 h. The mixture was cooled to RT, diluted with MeOH and filtered through a pad of Celite. The filtrate was concentrated. The resulting brown residue was purified by column chromatography (0-70% acetone in hexanes) to provide the title compound as a brown amorphous solid. MS (ESI, pos. ion) m/z: 341.2 (M+1).

Provenance & Evidence