2,4-Difluoroaniline → HCID 45280243, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-bromo-1-(1,1,1-trifluoropropan-2-yloxy)phthalazine (0.130 g, 0.40 mmol), sodium t-butoxide (0.056 g, 0.58 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.016 g, 0.017 mmol), 2-(dicyclohexylphosphino)biphenyl (0.022 g, 0.063 mmol) and 2,4-difluoroaniline (0.060 ml, 0.60 mmol) in 1.5 mL of toluene was heated at 140° C. for 15 min in the microwave (Initiator by Biotage). The mixture was diluted with MeOH, evaporated onto silica gel and purified by flash chromatography (ISCO 12 g, eluting with 15-75% EtOAc in hexanes) to give the title compound as a light-yellow amorphous solid. MS (ESI, pos. ion) m/z: M+1=370.1

Provenance & Evidence