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HRID 454908作成日：2026年10月25日
2-(Azetidin-3-yloxy)-3-(3,6-dihydro-2H-pyran-4-YL)pyridine hydrochloride → 2-(azetidin-3-yloxy)-3-(tetrahydro-2H-pyran-4-yl)pyridine
https://huagongshe.com/reaction/454908
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-(Azetidin-3-yloxy)-3-(3,6-dihydro-2H-pyran-4-YL)pyridine hydrochloride | HCID 67477450 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(azetidin-3-yloxy)-3-(tetrahydro-2H-pyran-4-yl)pyridine | HCID 58547765 | 97.3% |
反応手順
A mixture of 2-(azetidin-3-yloxy)-3-(3,6-dihydro-2H-pyran-4-yl)pyridine hydrochloride (see PREPARATION P26.1; 3.5 g, 15 mmol) and wet Pd—C (50%, 1.0 g) in MeOH (100 ml) was stirred under H2 (40 psi) at 30° C. for 3 hours then the reaction mixture was filtered through CELITE® and the filtrate was concentrated in vacuo to give the title compound (3.2 g, 14.6 mmol, yield 91%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08497265B2 |
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| 出典データセット | uspto-grants-2013_07 |
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| ORD ID | ord-bf1e0e2146dd457d8b9c5e9e987f429a |
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| 出典メモ | uspto-grants-2013_07 |
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