4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → 3-(3,4-Difluoro-phenyl)-N-methyl-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide
Reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[C:16]([F:21])[CH:15]=2)[CH2:9][C:10]([NH:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.CC1(C)C(C)(C)OB([C:30]2[CH:31]=[N:32][NH:33][CH:34]=2)O1>>[F:21][C:16]1[CH:15]=[C:14]([CH:8]([C:5]2[CH:6]=[CH:7][C:2]([C:30]3[CH:31]=[N:32][NH:33][CH:34]=3)=[CH:3][CH:4]=2)[CH2:9][C:10]([NH:12][CH3:13])=[O:11])[CH:19]=[CH:18][C:17]=1[F:20]Participants
3
Procedure
3-(4-Bromo-phenyl)-3-(3,4-difluoro-phenyl)-N-methyl-propionamide was reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole following the procedure set out in Example 1 to give the title compound. LC/MS: (PS-A2) Rt 2.55 [M+H]+ 341.93.
Sources & evidence
- ORD record
- ord-e07e8920586447e28e5753169c07dc8f
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08541461B2
Reaction notes
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