HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (βR)-β-Amino-4-bromobenzeneethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-tert-butyl (1-(4-bromophenyl)-2-hydroxyethyl)carbamate | HCID 12194286 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (βR)-β-Amino-4-bromobenzeneethanol | HCID 14853191 | 116.5% |
Reaction Steps
A solution of [(R)-1-(4-bromo-phenyl)-2-hydroxy-ethyl]-carbamic acid t-butyl ester (946 mg, 3 mmol) in MeOH (15 ml) was treated with HCl in dioxane (4 M, 15 ml) for 1.5 h. The mixture was concentrated to give the titled compound (755 mg, 100%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497271B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-a73a874f4f6e4c08883a880458021e51 |
| Source note | uspto-grants-2013_07 |