HuagongsheHuagongshe Chemistry Print Report · For research reference only
[(R)-2-Hydroxy-1-(4-methoxy-phenyl)-ethyl]-carbamic acid benzyl ester → (R)-2-Amino-2-(4-methoxyphenyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [(R)-2-Hydroxy-1-(4-methoxy-phenyl)-ethyl]-carbamic acid benzyl ester | HCID 10957582 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-2-Amino-2-(4-methoxyphenyl)ethanol | HCID 10866717 | 102.1% |
Reaction Steps
A mixture of [(R)-2-Hydroxy-1-(4-methoxy-phenyl)-ethyl]-carbamic acid benzyl ester (761 mg, 2.53 mmol) and Pd/C (76 mg) in MeOH (8 mL) was stirred under H2 (1 atm) for 1.5 h. The mixture was filtered and the filtrate was concentrated to give the titled compound (432 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497271B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-4d7ab107b2a0412cb75ad6324915fa04 |
| Source note | uspto-grants-2013_07 |