HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 67073663, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | Water ethylacetate | HCID 22728543 | — |
| Reactant | HCID 67073707 | HCID 67073707 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67073663 | HCID 67073663 | 59% |
Reaction Steps
A mixture of [(R)-2-hydroxy-1-(4-hydroxy-2-methoxy-phenyl)-ethyl]-carbamic acid benzyl ester (736.3 mg, 2.32 mmol), TBSCl (840.2 mg, 5.57 mmol) and imidazole (757.2 mg, 11.1 mmol) in DCM was stirred at rt for 24 h. The reaction was worked up with EtOAc/H2O. Flash column provided the titled compound (585.7 mg, 59%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497271B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-cff9cc18393f464c8d9cc413c8903e49 |
| Source note | uspto-grants-2013_07 |