Tetrabutylammonium Fluoride → HCID 86658148, compound

Participants

Reaction Steps

To the (1S,2S)-2-Thiophen-2-yl-cyclopropanecarboxylic acid {(R)-1-[4-(tert-butyl-dimethyl-silanyloxy)-2-methoxy-phenyl]-2-hydroxy-ethyl}-amide (393.4 mg, 0.88 mmol) dissolved in 20 ml THF at 0° C., was added 1.32 ml TBAF (1.0 M solution, 1.32 mmol). The ice bath was remove and stirred for 2 hr at rt. It was diluted with ether and quenched with aq. NH4Cl. The organic layer was washed with water and brine, and then dried over MgSO4. It was concentrated and purified on flash column (6% MeOH in DCM) to obtain the titled compound (used directly for next reaction).

Provenance & Evidence