Potassium Hydroxide → HCID 67430848, compound

Participants

Reaction Conditions

Reaction Steps

To 200 mg (0.49 mmol) of (R)-2-Amino-2-[4-((S)-2-methyl-butoxy)-phenyl]-1-(4-methyl-piperazin-1-yl)-ethanone di-HCl salt in 10 mL of THF was added 5.9 mL LAH (1.0 M solution, 4.9 mmol). The resulting mixture was refluxed overnight. On the next day it was cooled to 0° C. and 0.5 mL of concentrated aq. KOH was slowly added. The ice bath was removed, and allowed it to stir for 1 hr, and then diluted with EtOAc, dried over MgSO4, filter and concentrated to obtain 68 mg (44%) of the product. The product obtained was pure enough to be used for the next step without further purification.

Provenance & Evidence