HuagongsheHuagongshe Chemistry Print Report · For research reference only
ethyl 1H-imidazole-2-carboxylate → 1-(6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-1H-imidazole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ethyl 1H-imidazole-2-carboxylate | HCID 549404 | — |
| Reactant | 3-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine | HCID 58337071 | — |
| Reactant | 3-(Chloromethyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine hydrochloride | HCID 67028724 | — |
| Product | 1-(6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-1H-imidazole-2-carboxylic acid ethyl ester | HCID 67028673 | — |
Reaction Steps
The title compound was prepared according to Method A and the experimentals described for compound 1 from 3-(chloromethyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine hydrochloride and ethyl 1H-imidazole-2-carboxylate. m/e+ 375 for C22H23N4O2 [M+H]+; 1H-NMR (300 MHz, CDCl3) δ 7.63 (m, 4H), 7.24 (m, 4H), 6.73 (d, J=0.9 Hz, 1H), 6.07 (s, 2H), 4.39 (m, 2H), 2.39 (s, 3H), 2.29 (s, 3H), 1.43 (m, 3H) ppm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497278B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-2ae8a64d12734043bfbcf62127de7714 |
| Source note | uspto-grants-2013_07 |