3-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine → HCID 67028656, compound

HRID 455026Notes

Reaction equation

HRID 455026 reaction equation
N1(CC2N3C=C(C)C=CC3=NC=2C2C=CC(C)=CC=2)C=CN=C1.[CH3:24][O:25][C:26]([C:28]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[NH:30][N:29]=1)=[O:27].Cl.Cl[CH2:39][C:40]1[N:44]2[CH:45]=[CH:46][CH:47]=[CH:48][C:43]2=[N:42][C:41]=1[C:49]1[CH:54]=[CH:53][C:52]([Cl:55])=[CH:51][CH:50]=1>>[Cl:55][C:52]1[CH:51]=[CH:50][C:49]([C:41]2[N:42]=[C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][N:44]3[C:40]=2[CH2:39][N:30]2[C:31]3[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:28]([C:26]([O:25][CH3:24])=[O:27])=[N:29]2)=[CH:54][CH:53]=1

Participants

3

Reactant 2

HCID 583370713-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridineHCID 67028996HCID 67028996, compound

Product 1

HCID 67028656HCID 67028656, compound

Procedure

The title compound was prepared according to Method A and the experimentals described for compound 1 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride methyl 1H-indazole-3-carboxylate. M/e+ 417 for C23H18ClN4O2 (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.22 (d, J=6.9 Hz, 1H), 8.03 (d, J=6.6 Hz, 1H), 7.83 (d, J=8.4 Hz, 2H), 7.68 (dd, J=8.8, 1.8 Hz, 2H), 7.41 (d, J=8.4 Hz, 2H), 7.30 (m, 2H), 7.24 (m, 1H), 6.81 (t, J=6.2 Hz, 1H), 6.47 (s, 2H), 4.03 (s, 3H) ppm.

Sources & evidence

ORD record
ord-20a4f0fc7d5b47c6a368f2738d8c6ad7
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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