Ethyl indole-2-carboxylate → Ethyl 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-indole-2-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	Ethyl indole-2-carboxylate	HCID 73125	—
Reactant	3-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine	HCID 58337071	—
Reactant	3-(Chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride	HCID 67028719	—
Product	Ethyl 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-indole-2-carboxylate	HCID 67028966	—

Reaction Steps

The title compound was prepared according to Method A and the experimentals described for compound 1 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and ethyl 1H-indole-2-carboxylate. M/e+ 430 for C25H21ClN3O2 (M+H)+; 1H-NMR (400 MHz, CD3OD) δ 8.13 (d, J=6.6 Hz, 1H), 7.70 (dd, J=8.4, 2.2 Hz, 2H), 7.55 (d, J=9.1 Hz, 1H), 7.42 (d, J=8.4, 2.5 Hz, 2H), 7.33 (d, J=8.4 Hz, 1H), 7.25 (t, J=6.6 Hz, 1H), 7.10 (t, J=6.6 Hz, 1H), 6.79 (m, 1H), 6.67 (m, 1H), 6.61 (m, 2H), 5.03 (s, 2H), 4.44 (q, J=6.9 Hz, 2H), 1.39 (t, J=6.9 Hz, 3H) ppm.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08497278B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-2acf9409b90b4ce082ee14eb24bca091
Source note	uspto-grants-2013_07