Methyl indole-3-carboxylate → Methyl 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-indole-3-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	Methyl indole-3-carboxylate	HCID 589098	—
Reactant	3-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine	HCID 58337071	—
Reactant	3-(Chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride	HCID 67028719	—
Product	Methyl 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-indole-3-carboxylate	HCID 67028660	—

Reaction Steps

The title compound was prepared according to Method A and the experimentals described for compound 1 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and methyl 1H-indole-3-carboxylate. M/e+ 430 for C25H21ClN3O2 (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.24 (dd, J=5.8, 2.5 Hz, 1H), 7.74 (d, J=9.1 Hz, 2H), 7.66 (d, J=8.4 Hz, 1H), 7.64 (m, 1H), 7.51 (s, 1H), 7.48 (m, 1H), 7.42 (d, J=8.4 Hz, 2H), 7.31 (m, 2H), 7.29 (t, J=5.8 Hz, 1H), 6.80 (t, J=6.9 Hz, 1H), 5.67 (s, 2H), 3.83 (s, 3H) ppm.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08497278B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-9228fa87a5e54aefb95f31f2cfe0ad5c
Source note	uspto-grants-2013_07