反应详情

The title compound was prepared according to Method A and the experimentals described for compound 1 from 3-(chloromethyl)-6-fluoro-2-(4-fluorophenyl)imidazo[1,2-a]pyridine hydrochloride and methyl 1H-1,2,4-triazole-5-carboxylate. The two isomers were separated by silica gel chromatography eluted with 20% acetone to flash out the less polar spot and 50% acetone to flash out the second spot (more polar spot). m/e− 370 for C18H14F2N5O2 (M+H)−.

1. customThe two isomers were separated by silica gel chromatography
2. washeluted with 20% acetone to flash out the less polar spot and 50% acetone to flash out the second spot (more polar spot)