3-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine → HCID 67028685, compound

HRID 455035Notes

Reaction equation

HRID 455035 reaction equation
N1(CC2N3C=C(C)C=CC3=NC=2C2C=CC(C)=CC=2)C=CN=C1.Cl.[C:25]1(C2C=CC=CC=2)[CH:30]=[CH:29][C:28]([C:31]2[N:32]=[C:33]3[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][N:34]3[C:40]=2[CH2:41]Cl)=[CH:27][CH:26]=1.[NH:49]1[CH:53]=[CH:52][N:51]=[N:50]1>>[Cl:39][C:36]1[CH:37]=[CH:38][C:33]2[N:34]([C:40]([CH2:41][N:49]3[CH:53]=[CH:52][N:51]=[N:50]3)=[C:31]([C:28]3[CH:27]=[CH:26][CH:25]=[CH:30][CH:29]=3)[N:32]=2)[CH:35]=1

Participants

4

Reactant 3

HCID 583370713-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridineHCID 67029160HCID 67029160, compoundHCID 178418936HCID 178418936, compound

Product 1

HCID 67028685HCID 67028685, compound

Procedure

The title compound was prepared according to Method A and the experimentals described for compound 1 from 2-(biphenyl-4-yl)-6-chloro-3-(chloromethyl)imidazo[1,2-a]pyridine hydrochloride and 1H-1,2,3-triazole. (m, 3H), 7.62 (dd, J=0.7, 9.5 Hz, 1H), 7.52 (m, 2H), 7.46 (m, 2H), 7.26 (m, 1H), 5.99 (s, 2H) ppm.

Sources & evidence

ORD record
ord-f923db40515d4d92b8635b003e493b2e
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

Loading…