HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-N-methyl-1H-1,2,4-triazole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 2-(6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-2H-[1,2,4]triazole-3-carboxylic acid methylamide | HCID 67027485 | — |
| Reactant | methyl 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-1,2,4-triazole-3-carboxylate | HCID 67028970 | — |
| Product | 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-N-methyl-1H-1,2,4-triazole-3-carboxamide | HCID 67028209 | — |
Reaction Steps
The title compound was prepared according to the procedure described for compound 68 from methyl 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-1,2,4-triazole-3-carboxylate and methylamine. 1H-NMR (400 MHz, CDCl3, δ) 8.42 (d, J=6.8 Hz, 1H), 7.98 (d, J=8.5 Hz, 2H), 7.85 (s, 1H), 7.69 (d, J=9.1 Hz, 1H), 7.50 (broad, 1H), 7.45 (d, J=8.5 Hz, 2H), 7.29 (m, 1H), 6.87 (m, 1H), 6.34 (s, 2H), 3.08 (d, J=5.1 Hz, 3H) ppm; m/e 367, 369.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497278B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-85e1753118624b76861cda2692f57575 |
| Source note | uspto-grants-2013_07 |