Ammonia → 1-((2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl)methyl)-1H-imidazole-2-carboxamide

HRID 455050Notes

Reaction equation

HRID 455050 reaction equation
C[NH:2]C(C1N(CC2N3C=C(C)C=CC3=NC=2C2C=CC(C)=CC=2)N=CN=1)=O.[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([C:35]2[N:36]=[C:37]3[CH:42]=[CH:41][CH:40]=[N:39][N:38]3[C:43]=2[CH2:44][N:45]2[CH:49]=[CH:48][N:47]=[C:46]2[C:50]([O:52]C)=O)=[CH:31][CH:30]=1.N>>[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([C:35]2[N:36]=[C:37]3[CH:42]=[CH:41][CH:40]=[N:39][N:38]3[C:43]=2[CH2:44][N:45]2[CH:49]=[CH:48][N:47]=[C:46]2[C:50]([NH2:2])=[O:52])=[CH:31][CH:30]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 670274852-(6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-2H-[1,2,4]triazole-3-carboxylic acid methylamideHCID 67028990methyl 1-((2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl)methyl)-1H-imidazole-2-carboxylate

Product 1

HCID 445394351-((2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl)methyl)-1H-imidazole-2-carboxamide

Procedure

The title compound was prepared according to the procedure described for compound 68 from methyl 1-((2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl)methyl)-1H-imidazole-2-carboxylate and ammonia. 1H-NMR (CDCl3, 400 MHz, δ) 8.59 (d, J=4.4 Hz, 1H), 8.23 (d, J=9.2 Hz, 1H), 7.87 (s, 1H), 7.75 (d, J=8.5 Hz, 2H), 7.57 (s, 1H), 7.50 (d, J=8.4 Hz, 2H), 7.36 (dd, J=4.4, 9.2 Hz, 1H), 6.87 (s, 1H), 6.21 (s, 2H) ppm; m/e 353 (M+H)+.

Sources & evidence

ORD record
ord-f0e3129aa31d4a99a095a34b5f92d0b4
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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