Ammonia → 1-((2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl)methyl)-1H-1,2,4-triazole-5-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	2-(6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-2H-[1,2,4]triazole-3-carboxylic acid methylamide	HCID 67027485	—
Reactant	methyl 1-((2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl)methyl)-1H-1,2,4-triazole-5-carboxylate	HCID 67028747	—
Product	1-((2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl)methyl)-1H-1,2,4-triazole-5-carboxamide	HCID 44539437	—

Reaction Steps

The title compound was prepared according to the procedure described for compound 68 from methyl 1-((2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl)methyl)-1H-1,2,4-triazole-5-carboxylate and ammonia. 1H-NMR (CDCl3, 400 MHz, δ) 8.74 (s, 1H), 8.56 (dd, J=1.4, 4.5 Hz, 1H), 8.08 (dd, J=1.5, 9.3 Hz, 1H), 8.02 (d, J=8.5 Hz, 2H), 7.57 (d, J=8.5 Hz, 2H), 7.37 (dd, J=4.5, 9.2 Hz, 1H), 6.01 (s, 2H) ppm; m/e 354 (M+H)−.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08497278B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-e362a0204f10451bb205db6bc0725769
Source note	uspto-grants-2013_07