HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[2,2-Bis-(4-chloro-phenyl)-ethyl]-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-[2,2-Bis-(4-chloro-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 59331952 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-[2,2-Bis-(4-chloro-phenyl)-ethyl]-piperazine | HCID 59331941 | — |
Reaction Steps
4-[2,2-Bis-(4-chloro-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester was treated with HCl in ethyl acetate (saturated, 5 ml) for 1 hour, solvent removed under reduced pressure to afford the title compound as the HCl salt
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541461B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-8ced5fbea95245feb462cf7eefb7ef31 |
| Source note | uspto-grants-2013_09 |