Uracil → 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione

関与物質

反応手順

The title compound was prepared according to Method B and the experimentals described for compound 91 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and pyrimidine-2,4(1H,3H)-dione. M/e+ 353 for C18H14ClN4O2 (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.33 (d, J=5.8 Hz, 1H), 8.10 (s, 1H), 7.81 (d, J=8.4 Hz, 1H), 7.63 (d, J=8.4 Hz, 2H), 7.51 (d, J=8.4 Hz, 2H), 7.39 (td, J=6.9, 1.1 Hz, 1H), 7.00 (td, J=6.9, 1.1 Hz, 1H), 6.66 (d, J=8.0 Hz, 1H), 5.58 (d, J=8.0 Hz, 1H), 5.45 (s, 2H) ppm.

情報源と証拠