5-Fluorouracil → HCID 67028864, compound

HRID 455069Notes

Reaction equation

HRID 455069 reaction equation
Cl.Cl[CH2:3][C:4]1[N:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]2=[N:6][C:5]=1[C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1.[F:20][C:21]1[C:22](=[O:28])[NH:23][C:24](=[O:27])[NH:25][CH:26]=1>>[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([C:5]2[N:6]=[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][N:8]3[C:4]=2[CH2:3][N:25]2[CH:26]=[C:21]([F:20])[C:22](=[O:28])[NH:23][C:24]2=[O:27])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 33855-FluorouracilHCID 670287193-(Chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride

Product 1

HCID 67028864HCID 67028864, compound

Procedure

The title compound was prepared according to Method B and the experimentals described for compound 92 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and 5-fluoropyrimidine-2,4(1H,3H)-dione. M/e+ 371 for C18H13ClFN4O2 (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.22 (d, J=6.9 Hz, 1H), 7.71 (d, J=8.8 Hz, 1H), 7.67 (d, J=8.4 Hz, 2H), 7.52 (d, J=8.4 Hz, 2H), 7.36 (m, 1H), 6.96 (m, 1H), 6.69 (d, J=5.5 Hz, 1H), 5.45 (s, 2H) ppm.

Sources & evidence

ORD record
ord-e8999af40d38455abc0679a17293d6ae
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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