tert-Butyl piperazine-1-carboxylate → 1-{2-(4-Chloro-phenyl)-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethyl}-piperidine

Participants

Role	Name	HCID	Charge
Reactant	tert-Butyl piperazine-1-carboxylate	HCID 143452	—
Reactant	1-{2-(4-Chloro-phenyl)-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethyl}-piperazine	HCID 11451440	—
Reactant	4-[2,2-Bis-(4-chloro-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester	HCID 59331952	—
Product	1-{2-(4-Chloro-phenyl)-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethyl}-piperidine	HCID 11417238	—

Reaction Steps

By following the procedure described in Example 33A, 33B and 33D but substituting piperidine for N—BOC-piperazine, the title compound was obtained. LC/MS: (PS-A2) Rt 2.21 [M+H]+ 366.09. 1H NMR (Me-d3-OD) δ 1.44 (2H, m), 1.53 (4H, m), 2.39-2.57 (4H, m), 2.94-3.09 (2H, m), 4.26 (1H, t), 7.22-7.35 (6H, m), 7.50 (2H, d), 7.91 (2H, s).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08541461B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-05322ad904e34a5d9a8bdc5e8b1ec487
Source note	uspto-grants-2013_09