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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 455088Generated: October 27, 2026

Thiophenol → 6-Methyl-3-phenylsulfanylmethyl-2-p-tolyl-imidazo[1,2-a]pyridine

https://huagongshe.com/reaction/455088

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThiophenolHCID 7969—
Reactant3-(Chloromethyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine hydrochlorideHCID 67028724—
Product6-Methyl-3-phenylsulfanylmethyl-2-p-tolyl-imidazo[1,2-a]pyridineHCID 67027725—

Reaction Steps

The title compound was prepared according to Method A and the experimentals described for compound 139 from 3-(chloromethyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine hydrochloride and benzenethiol. m/e+ 345 for C22H21N2 (M+H)+; 1H NMR (400 MHz, CDCl3) δ 7.81 (s, 1H), 7.59 (d, J=8.0 Hz, 2H), 7.54 (d, J=9.1 Hz, 1H), 7.35 (d, J=1.8 Hz, 2H), 7.32 (m, 5H), 7.07 (d, J=9.1 Hz, 1H), 4.54 (s, 2H), 2.39 (s, 3H), 2.34 (s, 3H) ppm.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08497278B2
Source datasetuspto-grants-2013_07
ORD IDord-ccd6cb70367e43adb80652e76945b2ae
Source noteuspto-grants-2013_07