2-Amino-4,6-difluoropyrimidine → 4,6-difluoro-N-((2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2-amine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Amino-4,6-difluoropyrimidine	HCID 1201480	—
Edukt	3-(Chloromethyl)-2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridine hydrochloride	HCID 67028789	—
Produkt	4,6-difluoro-N-((2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2-amine	HCID 67028731	39%

Reaktionsschritte

The title compound was prepared according to Method A and the experimentals described for compound 139 from 3-(chloromethyl)-2-(4-fluorophenyl)-6-methylimidazo[1,2-a]pyridine hydrochloride and 4,6-difluoropyrimidin-2-amine. (0.23 g, 39% yield), M/e+ 370.1 for C19H14F3N5 (M+H)+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08497278B2
Quelldatensatz	uspto-grants-2013_07
ORD ID	ord-981d85149e954738bab827775927c37d
Quellennotiz	uspto-grants-2013_07