2-Amino-4,6-difluoropyrimidine → N-((6-Chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4,6-difluoropyrimidin-2-amine

HRID 455094Notes

Reaction equation

HRID 455094 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([CH2:19]Cl)=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[N:11]=2)[CH:8]=1.[F:21][C:22]1[CH:27]=[C:26]([F:28])[N:25]=[C:24]([NH2:29])[N:23]=1>>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([CH2:19][NH:29][C:24]3[N:25]=[C:26]([F:28])[CH:27]=[C:22]([F:21])[N:23]=3)=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[N:11]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 12014802-Amino-4,6-difluoropyrimidineHCID 670286376-Chloro-3-(chloromethyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine hydrochloride

Product 1

HCID 67028720N-((6-Chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4,6-difluoropyrimidin-2-amineYield 45%

Procedure

The title compound was prepared according to Method A and the experimentals described for compound 139 from 6-chloro-3-(chloromethyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine hydrochloride and 4,6-difluoropyrimidin-2-amine. (0.42 g, 45% yield). M/e+ 390.2 for C18H11ClF3N5 (M+H)+.

Sources & evidence

ORD record
ord-a1f35b95f5704c358b84b911452bfbf2
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

Loading…