2-Amino-4-chloro-6-methylpyrimidine → 4-chloro-N-((6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-6-methylpyrimidin-2-amine

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Reaction Steps

The title compound was prepared according to Method A and the experimentals described for compound 139 from 6-chloro-3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and 4-chloro-6-methylpyrimidin-2-amine. 1H-NMR (400 MHz, CDCl3) δ 8.56 (s, 1H), 7.69 (d, J=8.4 Hz, 2H), 7.55 (d, J=9.5 Hz, 1H), 7.40 (d, J=8.5 Hz, 2H), 7.18 (dd, J=1.8, 9.5 Hz, 1H), 6.55 (s, 1H), 5.59 (broad, 1H), 4.99 (d, J=5.6 Hz, 2H), 2.34 (s, 3H); m/e+ 419 for C19H14Cl3N5 [M+H]+.

Provenance & Evidence