2-Aminoimidazole → (6,8-Dichloro-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-(1H-imidazol-2-yl)-amine

HRID 455096Notes

Reaction equation

HRID 455096 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([Cl:21])[C:6]2[N:7]([C:9]([CH2:19]Cl)=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=3)[N:11]=2)[CH:8]=1.[NH:22]1[CH:26]=[CH:25][N:24]=[C:23]1[NH2:27]>>[Cl:2][C:3]1[CH:4]=[C:5]([Cl:21])[C:6]2[N:7]([C:9]([CH2:19][NH:27][C:23]3[NH:22][CH:26]=[CH:25][N:24]=3)=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=3)[N:11]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 821402-AminoimidazoleHCID 670289006,8-Dichloro-3-(chloromethyl)-2-p-tolylimidazo[1,2-a]pyridine hydrochloride

Product 1

HCID 67028809(6,8-Dichloro-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-(1H-imidazol-2-yl)-amine

Procedure

The title compound was prepared according to Method A and the experimentals described for compound 139 from 6,8-dichloro-3-(chloromethyl)-2-p-tolylimidazo[1,2-a]pyridine hydrochloride and 1H-imidazol-2-amine. m/e+ 372 for C18H16Cl2N5 [M+H]+; 1H-NMR (300 MHz, CDCl3) δ 8.10 (s, 1H), 7.27 (m, 4H), 6.92 (d, J=6.6 Hz, 2H), 6.76 (s, 2H), 4.67 (s, 2H), 4.50 (bs, 1H), 2.31 (s, 3H) ppm.

Sources & evidence

ORD record
ord-b0a68c471e884bf8bac11f0aa0bc9a41
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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