3-(Chloromethyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine hydrochloride → HCID 178423930, compound

HRID 455099Notes

Reaction equation

HRID 455099 reaction equation
Cl.Cl[CH2:3][C:4]1[N:8]2[CH:9]=[C:10]([CH3:13])[CH:11]=[CH:12][C:7]2=[N:6][C:5]=1[C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1.[NH:21]1[CH:25]=[N:24][C:23]([SH:26])=[N:22]1>>[CH3:13][C:10]1[CH:11]=[CH:12][C:7]2[N:8]([C:4]([CH2:3][S:26][C:23]3[N:24]=[CH:25][NH:21][N:22]=3)=[C:5]([C:14]3[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=3)[N:6]=2)[CH:9]=1

Participants

3

Reactant 2

HCID 670287243-(Chloromethyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine hydrochlorideHCID 178527894HCID 178527894, compound

Product 1

HCID 178423930HCID 178423930, compound

Procedure

The title compound was prepared according to Method A and the experimentals described for compound 139 from 3-(chloromethyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine hydrochloride and 1H-1,2,4-triazole-3-thiol. m/e+ 336 for C18H18N5S (M+H)+; 1H NMR (400 MHz, CDCl3) δ␣ 8.10 (s, 1H), 7.90 (s, 1H), 7.57 (m, 3H), 7.21 (d, J=7.7 Hz, 2H), 7.11 (dd, J=1.1, 9.1 Hz, 1H), 4.78 (s, 2H), 2.36 (s, 3H), 2.33 (s, 3H) 0.90 (bs, 1H) ppm.

Sources & evidence

ORD record
ord-5665698bb1db4ecea1d9ec5599c30df9
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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