HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4,6-difluoropyrimidine → 4,6-Difluoro-N-((6-fluoro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4,6-difluoropyrimidine | HCID 1201480 | — |
| Reactant | 3-(Chloromethyl)-6-fluoro-2-(4-fluorophenyl)imidazo[1,2-a]pyridine hydrochloride | HCID 67030270 | — |
| Product | 4,6-Difluoro-N-((6-fluoro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2-amine | HCID 67027728 | 39% |
Reaction Steps
The title compound was prepared according to Method A and the experimentals described for compound 139 from 3-(chloromethyl)-6-fluoro-2-(4-fluorophenyl)imidazo[1,2-a]pyridine hydrochloride and 4,6-difluoropyrimidin-2-amine. (0.35 g, 39% yield). M/e+ 374.2 for C18H11F4N5 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497278B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-3d82cc2f8f8b4a9980ad6043dfee033c |
| Source note | uspto-grants-2013_07 |