4-Hydroxypyrrolidine → 1-(2-((6-Chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methylamino)pyrimidin-4-yl)pyrrolidin-3-ol

関与物質

反応手順

The title compound was prepared in the same fashion as that described for compound 187 from N-((6-chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2-amine and pyrrolidin-3-ol. 1H-NMR (CDCl3, 400 MHz, δ) 8.72 (d, J=11.6 Hz, 1H), 8.32 (s, 1H), 7.78 (dd, J=5.7, 8.3 Hz, 2H), 7.66 (s, 1H), 7.61 (d, J=9.6 Hz, 2H), 7.41 (d, J=9.6 Hz, 1H), 7.26 (t, J=8.7 Hz, 2H), 6.13 (dd, J=6.3, 21.2 Hz, 1H), 5.10 (s, 2H), 4.88 (, 1H), 4.48 (d, J=36.5 Hz, 1H), 3.60 (m, 1H), 3.52 (m, 1H), 3.42 (m, 1H), 2.42 (m, 2H) ppm; m/e 439 (M+H)+.

情報源と証拠