N,N-Dimethylethylenediamine → N1-(6-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrazin-2-yl)-N2,N2-dimethylethane-1,2-diamine

Participants

Role	Name	HCID	Charge
Reactant	N,N-Dimethylethylenediamine	HCID 66053	—
Reactant	1-(2-((6-Chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methylamino)pyrimidin-4-yl)-4-methylpiperidin-4-ol	HCID 67029099	—
Reactant	2-(4-Chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine	HCID 86655124	—
Product	N1-(6-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrazin-2-yl)-N2,N2-dimethylethane-1,2-diamine	HCID 67308371	—

Reaction Steps

The title compound was prepared in the same fashion as that described for compound 187 from 2-(4-chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine and N1,N1-dimethylethane-1,2-diamine. M/e+ 407 for C22H24ClN6 (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.12 (d, J=6.9 Hz, 1H), 7.85 (d, J=8.8 Hz, 2H), 7.78 (s, 1H), 7.63 (d, J=8.4 Hz, 2H), 7.42 (d, J=8.4 Hz, 2H), 7.20 (m, 1H), 6.78 (m, 1H), 5.30 (s, 1H), 4.34 (s, 2H), 3.29 (q, J=5.5 Hz, 2H), 2.46 (t, J=5.5 Hz, 2H), 2.21 (s, 6H) ppm.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08497278B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-01aa3763eac14504b28b465dbcd13fc3
Source note	uspto-grants-2013_07