4-Hydroxypyrrolidine → 1-(6-((2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrazin-2-yl)pyrrolidin-3-ol

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	4-Hydroxypyrrolidine	HCID 98210	—
Edukt	1-(2-((6-Chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methylamino)pyrimidin-4-yl)-4-methylpiperidin-4-ol	HCID 67029099	—
Edukt	2-(4-Chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine	HCID 86655124	—
Produkt	1-(6-((2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrazin-2-yl)pyrrolidin-3-ol	HCID 67028905	—

Reaktionsschritte

The title compound was prepared according to the experimental for compound 187 from 2-(4-chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine and pyrrolidin-3-ol. M/e+ 406 for C22H21ClN5O (M+H)−; 1H-NMR (400 MHz, CDCl3) δ 8.20 (d, J=6.2 Hz, 1H), 7.89 (d, J=8.4 Hz, 2H), 7.71 (d, J=10.6 Hz, 2H), 7.59 (dd, J=9.1, 0.7 Hz, 1H), 7.41 (d, J=8.4 Hz, 2H), 7.16 (m, 1H), 6.77 (t, J=6.9 Hz, 1H), 4.56 (s, 1H), 4.32 (s, 2H), 4.06 (m, 1H), 3.53 (m, 3H), 3.00 (bs, 1H), 2.04 (m, 2H) ppm.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08497278B2
Quelldatensatz	uspto-grants-2013_07
ORD ID	ord-7d5ca89ac59d43a59a571690b0b2dd20
Quellennotiz	uspto-grants-2013_07