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2-(4-Chlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde → 3-((2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-5-methyl-1,2,4-oxadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(4-Chlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde | HCID 2757793 | — |
| 反応物 | 5-Methyl-1,2,4-oxadiazole | HCID 18382065 | — |
| 反応物 | 6-fluoro-2-(4-fluorophenyl)-3-((1-methyl-1H-imidazol-2-yl)methyl)imidazo[1,2-a]pyridine | HCID 67029064 | — |
| 生成物 | 3-((2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-5-methyl-1,2,4-oxadiazole | HCID 67028975 | — |
反応手順
The title compound was prepared according to Method C and the experimentals described for compound 199 from 2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde and 5-methyl-1,2,4-oxadiazole. M/e+ 325 for C17H14ClN4O (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.22 (d, J=6.9 Hz, 1H), 7.91 (d, J=8.4 Hz, 2H), 7.66 (d, J=8.8 Hz, 1H), 7.47 (d, J=8.4 Hz, 2H), 7.23 (m, 1H), 6.88 (t, J=6.9 Hz, 1H), 4.42 (d, J=0.7 Hz, 2H), 2.56 (s, 3H) ppm.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08497278B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-55977095bc1446278e22070381eb2507 |
| 出典メモ | uspto-grants-2013_07 |