HCID 67027678, compound → HCID 67028727, compound

HRID 455141Notes

Reaction equation

HRID 455141 reaction equation
[N:1]1[NH:2][N:3]=[C:4]([CH2:6][C:7]2[N:11]3[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:10]3=[N:9][C:8]=2[C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[CH:5]=1.Cl.Cl[C:26]1C=CC2N(C(CCl)=C(C3C=CC(Cl)=CC=3)N=2)C=1.C([Mg]Br)#CC>>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]2[N:11]([C:7]([CH2:6][C:4]3[C:5]([CH3:26])=[N:1][NH:2][N:3]=3)=[C:8]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)[N:9]=2)[CH:12]=1

Participants

4

Reactant 3

HCID 67027678HCID 67027678, compoundHCID 67028658HCID 67028658, compoundHCID 178419101HCID 178419101, compound

Product 1

HCID 67028727HCID 67028727, compound

Procedure

The title compound was prepared according to the experimental described for compound 227 from 6-chloro-3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and prop-1-ynylmagnesium bromide. m/e+ 359 for C17H14Cl2N5 (M+H)+.

Sources & evidence

ORD record
ord-91bf4bc3c399496a8e55e2e0db1aac38
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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