Acetamidine monohydrochloride → HCID 178434007, compound

HRID 455147Notes

Reaction equation

HRID 455147 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][C:18]2[NH:22][C:21]([C:23]3C=CC=CN=3)=[N:20][N:19]=2)=[CH:4][CH:3]=1.[Cl:29]C1C=CC2N(C(CC(NN)=O)=C(C3C=CC=CC=3)N=2)C=1.Cl.C(=N)(N)C>>[Cl:29][C:13]1[CH:14]=[CH:15][C:10]2[N:11]([C:16]([CH2:17][C:18]3[NH:22][C:21]([CH3:23])=[N:20][N:19]=3)=[C:8]([C:5]3[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=3)[N:9]=2)[CH:12]=1

Participants

4

Reactant 3

HCID 67170Acetamidine monohydrochlorideHCID 670288652-(6-Chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)acetohydrazideHCID 178477970HCID 178477970, compound

Product 1

HCID 178434007HCID 178434007, compound

Procedure

The title compound was prepared according to the experimental described for compound 230 from 2-(6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)acetohydrazide and acetimidamide hydrochloride. M/e− 324 for C17H15ClN5 (M+H)+; 1H-NMR (400 MHz, CD3OD) δ 8.43 (s, 1H), 7.74 (d, J=8.4 Hz, 2H), 7.63 (m, 1H), 7.57 (d, J=9.9 Hz, 1H), 7.46 (d, J=8.4 Hz, 2H), 7.39 (m, 2H), 4.46 (s, 2H), 2.38 (s, 3H) ppm.

Sources & evidence

ORD record
ord-7809c79782624db194cfbc9c1c6ea55c
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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