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Ammonia → 2-(4-Chloro-phenyl)-N-methyl-2-[4-(1H-pyrazol-4-yl)-phenyl]-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | Bis(4-chlorophenyl)acetic acid | HCID 6730 | — |
| 反応物 | 3-(4-Chloro-phenyl)-3-[4-(1H-pyrazol-4-yl)-phenyl]-propylamine | HCID 11771347 | — |
| 生成物 | 2-(4-Chloro-phenyl)-N-methyl-2-[4-(1H-pyrazol-4-yl)-phenyl]-acetamide | HCID 11359296 | — |
反応手順
By following the procedure described in Example 12A followed by 12C but substituting 3-(4-Bromo-phenyl)-3-(4-chloro-phenyl)-propionic acid for Bis-(4-chloro-phenyl)-acetic acid and ammonia for methyl amine, the title compound was obtained. LC/MS (PS-A2): Rt 2.64 [M+H]+ 326. 1H NMR (Me-d3-OD) δ 2.79 (3H, s), 4.94, (1H, br s), 7.26-7.35 (6H, m), 7.55-7.57 (2H, m), 7.96 (2H, br s)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541461B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-0f2d2933f63947e9ba09cb001871bc4d |
| 出典メモ | uspto-grants-2013_09 |