2-(4-Bromophenyl)imidazo[1,2-a]pyridine-3-methanamine → HCID 67029137, compound

HRID 455155Notes

Reaction equation

HRID 455155 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][N:18]2[CH2:22][C:21]([NH:23][CH2:24][CH2:25][N:26]([CH3:28])[CH3:27])=[CH:20][C:19]2=[O:29])=[CH:4][CH:3]=1.[Br:30]C1C=CC(C2N=C3C=CC=CN3C=2CN)=CC=1>>[Br:30][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][N:18]2[CH2:22][C:21]([NH:23][CH2:24][CH2:25][N:26]([CH3:28])[CH3:27])=[CH:20][C:19]2=[O:29])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27571202-(4-Bromophenyl)imidazo[1,2-a]pyridine-3-methanamineHCID 67029115HCID 67029115, compound

Product 1

HCID 67029137HCID 67029137, compound

Procedure

The title compound was prepared according to the experimental for compound 237 from (2-(4-bromophenyl)imidazo[1,2-a]pyridin-3-yl)methanamine. m/e+=454 (M+H+). 1H-NMR (400 MHz, CDCl3, δ): 8.51 (d, 1H, D, J=5.8 Hz), 7.63 (m, 5H), 7.26 (m, 1H), 6.85 (t, 1H, D, J=6.6 Hz), 5.06 (s, 2H), 4.88 (m, 1H), 4.67 (s, 1H), 3.55 (s, 1H), 2.99 (m, 2H), 2.42 (m, 2H), 2.16 (s, 6H).

Sources & evidence

ORD record
ord-fbe074bb9535473c88a1637ac03e6a75
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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