反应详情

Potassium thiocyanate (4.3 g, 44.2 mmol) was suspended in acetic acid (40 mL), and the mixture was stirred at room temperature for 10 min. N-[3-(4-Amino-2-nitrophenoxy)phenyl]-2,2,2-trifluoroacetamide (3.02 g, 8.85 mmol) was added to the obtained solution, and the mixture was further stirred at room temperature for 10 min. A solution of bromine (1.98 g, 12.4 mmol) in acetic acid (10 mL) was slowly added dropwise to the obtained solution, and the mixture was stirred at room temperature for 16 hr. The resulting yellow insoluble material was filtered off and washed with acetic acid. The filtrate and washings were combined and the mixture was concentrated under reduced pressure. The obtained residue was suspended in ethyl acetate (400 mL), and washed with saturated aqueous sodium hydrogen carbonate solution (400 mL). The aqueous layer was extracted with ethyl acetate (200 mL), and the combined organic layer was washed with saturated brine (400 mL), and dried over anhydrous sodium sulfate. Insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (ethyl acetate/n-hexane=40/60→100/0), and the obtained solution was concentrated under reduced pressure. The residue was crystallized from ethyl acetate/n-hexane to give the title compound (1.29 g, 37%) as a yellow powder.

1. stirringthe mixture was further stirred at room temperature for 10 min
2. stirringthe mixture was stirred at room temperature for 16 hr
3. filtrationThe resulting yellow insoluble material was filtered off
4. washwashed with acetic acid
5. concentrationthe mixture was concentrated under reduced pressure
6. washwashed with saturated aqueous sodium hydrogen carbonate solution (400 mL)
7. extractionThe aqueous layer was extracted with ethyl acetate (200 mL)
8. washthe combined organic layer was washed with saturated brine (400 mL)
9. dry with materialdried over anhydrous sodium sulfate
10. filtrationInsoluble material was filtered off
11. concentrationthe filtrate was concentrated under reduced pressure
12. customThe residue was purified by basic silica gel column chromatography (ethyl acetate/n-hexane=40/60→100/0)
13. concentrationthe obtained solution was concentrated under reduced pressure
14. customThe residue was crystallized from ethyl acetate/n-hexane