Water → HCID 70976150, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of (6R,7aS)-6-Bromo-2-(4-trifluoromethoxy-phenyl)-hexahydro-pyrrolo[1,2-c]imidazol-3-one (example 20, step b) (1.45 g, 4 mmol) and NaN3 (0.34 g, 5.2 mmol) in DMF (50 mL) was heated to 70° C. for 1.5 h. Then to the mixture was added water (100 mL) and extracted with EtOAc (100 mL×2), the organic layer was washed water (100 mL) and brine (100 mL). The combined organic layer was evaporated to dryness and the crude product (1.0 g, 77%) was used without further purification in the next step.

Provenance & Evidence