HCID 70976150, compound → HCID 70976021, compound

Participants

Reaction Steps

A mixture of crude (6S,7aS)-6-Azido-2-(4-trifluoromethoxy-phenyl)-hexahydro-pyrrolo[1,2-c]imidazol-3-one (example 20, step c) (0.90 g) and 10% Pd/C (0.18 g) was stirred in anhydrous THF (20 mL) at the H2 atmosphere for 1 h at 15° C. The mixture was filtered, concentrated and purified by silica gel column chromatography (eluting with DCM/MeOH=50:1˜10:1) to yield 0.70 g of the title compound as a grey solid. 1H NMR (300 MHz, d6-DMSO): δ 7.67 (d, 2H, J=3 Hz), 7.31 (d, 2H, J=9 Hz), 3.96 (d, 1H, J=12 Hz), 3.86 (d, 1H, J=12 Hz), 3.77-3.73 (m, 1H), 3.54-3.52 (m, 1H), 3.18-3.17 (m, 1H), 3.10-3.06 (m, 1H), 2.15-2.11 (m, 1H), 1.69 (s, 2H), 1.35-1.31 (m, 1H); LC-MS: 302.1 [M+1]+.

Provenance & Evidence