HCID 71699857, compound → HCID 86667508, compound

HRID 455296Notes

Reaction equation

HRID 455296 reaction equation
[C:1]([CH2:3][CH2:4][CH2:5][CH2:6][S:7]([NH:10][CH3:11])(=[O:9])=[O:8])#[N:2]>CO.[Pd]>[NH2:2][CH2:1][CH2:3][CH2:4][CH2:5][CH2:6][S:7]([NH:10][CH3:11])(=[O:9])=[O:8]

Participants

4

Reactant 1

HCID 71699857HCID 71699857, compound

Product 1

HCID 86667508HCID 86667508, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4-cyano-N-methylbutane-1-sulfonamide (Example 9; 91.2 mmol) and Pd/C (10 mol %, 1 g) in methanol/7N NH3 (180 ml) was put under a hydrogen atmosphere. The mixture was stirred overnight at room temperature. The mixture was filtered and concentrated. The crude product was used in the next step without further purification.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated
  3. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-eec8ba38422243a29f3cfee85e896b8a
Source dataset
uspto-grants-2013_07
Patent number
US08497270B2

Reaction notes

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