HRID455312

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)c1nc(Br)c2cccnc2c1OS(=O)(=O)c1ccc(C)cc1

HCID11339571

未命名化合物

HCID71699856

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1nc(N(C)S(=O)(=O)CCCCNC(=O)OC(C)(C)C)c2cccnc2c1OS(=O)(=O)c1ccc(C)cc1

HCID86667515

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in a similar fashion as described in Example 2.1, starting from methyl 5-bromo-8-(tosyloxy)-1,6-naphthyridine-7-carboxylate (Example 12; 10.3 mmol) and tert-butyl 4-(N-methylsulfamoyl)butylcarbamate (Example 8) to obtain the target compound (3.43 gr).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-15354045f7264a8ca2147ff21759fff4
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08497270B2
来源说明: uspto-grants-2013_07

反应 SMILES

Br[C:2]1[N:11]=[C:10]([C:12]([O:14][CH3:15])=[O:13])[C:9]([O:16][S:17]([C:20]2[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=2)(=[O:19])=[O:18])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[CH3:27][NH:28][S:29]([CH2:32][CH2:33][CH2:34][CH2:35][NH:36][C:37](=[O:43])[O:38][C:39]([CH3:42])([CH3:41])[CH3:40])(=[O:31])=[O:30]>>[C:39]([O:38][C:37]([NH:36][CH2:35][CH2:34][CH2:33][CH2:32][S:29]([N:28]([C:2]1[N:11]=[C:10]([C:12]([O:14][CH3:15])=[O:13])[C:9]([O:16][S:17]([C:20]2[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=2)(=[O:19])=[O:18])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2)[CH3:27])(=[O:31])=[O:30])=[O:43])([CH3:42])([CH3:41])[CH3:40]