反应详情

温度

75 °C

A mixture of 2-(2-methyl-3-trifluoromethyl-phenoxy)-butyronitrile (192 mg, 0.790 mmol), ethylene diamine (0.216 ml, 3.16 mmol) and sodium tetrasulfide (7 mg, 0.04 mmol) was stirred for 4 hrs at 75° C., then cooled and stirred with water (ca 6 ml). The solid was filtered off, washed with water and dried in a vacuum to yield 2-[1-(2-methyl-3-trifluoromethyl-phenoxy)-propyl]-4,5-dihydro-1H-imidazole (m.p. 120-122° C.).

1. temperaturecooled
2. filtrationThe solid was filtered off
3. washwashed with water
4. customdried in a vacuum