Chlorobenzene → 1-[3-(4-Bromo-phenyl)-3-(4-chloro-phenyl)-propyl]-1H-imidazole

Participants

Role	Name	HCID	Charge
Reactant	Chlorobenzene	HCID 7964	—
Reactant	1-(4-Bromo-phenyl)-3-imidazol-1-yl-propan-1-ol	HCID 21415362	—
Product	1-[3-(4-Bromo-phenyl)-3-(4-chloro-phenyl)-propyl]-1H-imidazole	HCID 59331951	67%

Reaction Steps

Chlorobenzene (5 ml) was reacted with 1-(4-Bromo-phenyl)-3-imidazol-1-yl-propan-1-ol (0.41 mg, 1.46 mmol) following the procedure set out in Example 42B to give the title compound (0.37 g, 67% yield). LC/MS: (PS-A2) Rt 2.40 [M+H]+ 375.16, 377.17.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08541461B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-a20027adbf184faa8a785a2a7f5217f1
Source note	uspto-grants-2013_09