Phenol → 1-[3-(4-Bromo-phenyl)-3-phenoxy-propyl]-1H-imidazole

HRID 45536Notes

Reaction equation

HRID 45536 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15](O)[CH2:16][CH2:17][N:18]2[CH:22]=[CH:21][N:20]=[CH:19]2)=[CH:11][CH:10]=1>>[Br:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([O:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:16][CH2:17][N:18]2[CH:22]=[CH:21][N:20]=[CH:19]2)=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 996PhenolHCID 214153621-(4-Bromo-phenyl)-3-imidazol-1-yl-propan-1-ol

Product 1

HCID 593319531-[3-(4-Bromo-phenyl)-3-phenoxy-propyl]-1H-imidazole

Procedure

Phenol was reacted with 1-(4-Bromo-phenyl)-3-imidazol-1-yl-propan-1-ol* following the procedure set out in Example 48B to give the title compound. LC/MS: (PS-A2) Rt 2.30 [M+H]+ 357.26, 359.27.

Sources & evidence

ORD record
ord-ab6aedfa9d064800a13bf4df35c2cf0e
Source dataset
uspto-grants-2013_09
Patent number
US08541461B2

Reaction notes

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