4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → HCID 59331976, compound

HRID 45539Notes

Reaction equation

HRID 45539 reaction equation
[CH2:1]([O:8][C:9](=[O:27])[NH:10][CH2:11][CH:12]([C:20]1[CH:25]=[CH:24][C:23](Br)=[CH:22][CH:21]=1)[C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC1(C)C(C)(C)OB([C:36]2[CH:37]=[N:38][NH:39][CH:40]=2)O1>>[CH2:1]([O:8][C:9](=[O:27])[NH:10][CH2:11][CH:12]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[C:20]1[CH:25]=[CH:24][C:23]([C:36]2[CH:37]=[N:38][NH:39][CH:40]=2)=[CH:22][CH:21]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27740104-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 59331926HCID 59331926, compound

Product 1

HCID 59331976HCID 59331976, compound

Procedure

[2-(4-Bromo-phenyl)-2-(4-fluoro-phenyl)-ethyl]-carbamic acid benzyl ester was reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole following the procedure set out in Example 1 to give the title compound. LC/MS: (PS-A2) Rt 3.20 [M+H]+ 416.

Sources & evidence

ORD record
ord-e8700176abe948bcb428e351256e06e4
Source dataset
uspto-grants-2013_09
Patent number
US08541461B2

Reaction notes

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